DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection.
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AuthorsWalker, Mark J
Sanderson-Smith, Martina L
Cole, Jason N
Kirk, Joshua K
McArthur, Jason D
Aziz, Ramy K
Kansal, Rita G
Simpson, Amelia J
Buchanan, John T
Chhatwal, Gursharan S
MetadataShow full item record
AbstractMost invasive bacterial infections are caused by species that more commonly colonize the human host with minimal symptoms. Although phenotypic or genetic correlates underlying a bacterium's shift to enhanced virulence have been studied, the in vivo selection pressures governing such shifts are poorly understood. The globally disseminated M1T1 clone of group A Streptococcus (GAS) is linked with the rare but life-threatening syndromes of necrotizing fasciitis and toxic shock syndrome. Mutations in the GAS control of virulence regulatory sensor kinase (covRS) operon are associated with severe invasive disease, abolishing expression of a broad-spectrum cysteine protease (SpeB) and allowing the recruitment and activation of host plasminogen on the bacterial surface. Here we describe how bacteriophage-encoded GAS DNase (Sda1), which facilitates the pathogen's escape from neutrophil extracellular traps, serves as a selective force for covRS mutation. The results provide a paradigm whereby natural selection exerted by the innate immune system generates hypervirulent bacterial variants with increased risk of systemic dissemination.
CitationDNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. 2007, 13 (8):981-5 Nat. Med.
AffiliationSchool of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia.
The following license files are associated with this item:
- The Mga Regulon but Not Deoxyribonuclease Sda1 of Invasive M1T1 Group A Streptococcus Contributes to In Vivo Selection of CovRS Mutations and Resistance to Innate Immune Killing Mechanisms.
- Authors: Liu G, Feng W, Li D, Liu M, Nelson DC, Lei B
- Issue date: 2015 Nov
- Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes.
- Authors: Aziz RK, Ismail SA, Park HW, Kotb M
- Issue date: 2004 Oct
- Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus.
- Authors: Tsatsaronis JA, Hollands A, Cole JN, Maamary PG, Gillen CM, Ben Zakour NL, Kotb M, Nizet V, Beatson SA, Walker MJ, Sanderson-Smith ML
- Issue date: 2013 Jul
- DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps.
- Authors: Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V
- Issue date: 2006 Feb 21
- Parameters governing invasive disease propensity of non-M1 serotype group A streptococci.
- Authors: Maamary PG, Sanderson-Smith ML, Aziz RK, Hollands A, Cole JN, McKay FC, McArthur JD, Kirk JK, Cork AJ, Keefe RJ, Kansal RG, Sun H, Taylor WL, Chhatwal GS, Ginsburg D, Nizet V, Kotb M, Walker MJ
- Issue date: 2010