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dc.contributor.authorVoss, Andreas
dc.contributor.authorBode, Günther
dc.contributor.authorSopalla, Claudia
dc.contributor.authorBenedyk, Malgorzata
dc.contributor.authorVarga, Georg
dc.contributor.authorBöhm, Markus
dc.contributor.authorNacken, Wolfgang
dc.contributor.authorKerkhoff, Claus
dc.date.accessioned2012-01-12T13:10:55Z
dc.date.available2012-01-12T13:10:55Z
dc.date.issued2011-01-21
dc.identifier.citationExpression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation. 2011, 585 (2):440-6 FEBS Lett.en
dc.identifier.issn1873-3468
dc.identifier.pmid21192933
dc.identifier.doi10.1016/j.febslet.2010.12.037
dc.identifier.urihttp://hdl.handle.net/10033/202630
dc.description.abstractS100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
dc.language.isoenen
dc.subject.meshAdaptation, Physiologicalen
dc.subject.meshCalgranulin Aen
dc.subject.meshCalgranulin Ben
dc.subject.meshCell Differentiationen
dc.subject.meshCell Lineen
dc.subject.meshCell Proliferationen
dc.subject.meshEpithelial Cellsen
dc.subject.meshHumansen
dc.subject.meshKeratinocytesen
dc.subject.meshNF-kappa Ben
dc.titleExpression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.en
dc.typeArticleen
dc.contributor.departmentInstitute of Immunology, University of Muenster, Muenster, Germany.en
dc.identifier.journalFEBS lettersen
refterms.dateFOA2018-06-13T16:03:08Z
html.description.abstractS100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.


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