• A Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention.

      Rieg, Siegbert; Bechet, Lena; Naujoks, Kai; Hromek, Julia; Lange, Berit; Juzek-Küpper, Marc-Fabian; Stete, Katarina; Müller, Matthias C; Jost, Insa; Kern, Winfried V; et al. (Oxford University Press, 2020-02-13)
      A total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (P < .001). Forty-four episodes of severe sepsis or septic shock occurred in study patients: 22 after study entry and 22 before study entry. Streptococcus pneumoniae was more frequent among sepsis episodes that occurred before study entry (8/22) than after study entry (1/22 episodes). For episodes occurring after study entry, only a higher Charlson comorbidity index score was significantly associated with severe sepsis/septic shock postsplenectomy.