Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection.

Bihrer, Verena; Friedrich-Rust, Mireen; Kronenberger, Bernd; Forestier, Nicole; Haupenthal, Jörg; Shi, Ying; Peveling-Oberhag, Jan; Radeke, Heinfried H; Sarrazin, Christoph; Herrmann, Eva; Zeuzem, Stefan; Waidmann, Oliver; Piiper, Albrecht

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Authors

Bihrer, Verena
Friedrich-Rust, Mireen
Kronenberger, Bernd
Forestier, Nicole
Haupenthal, Jörg
Shi, Ying
Peveling-Oberhag, Jan
Radeke, Heinfried H
Sarrazin, Christoph
Herrmann, Eva

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Issue Date

2011-09

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Abstract

The liver contains large amounts of microRNA-122 (miR-122), whereas other tissues contain only marginal amounts of this miRNA. MicroRNAs have also been found to circulate in the blood in a cell-free form; their potential as readily accessible disease markers is currently evaluated. Here, we investigated if the serum levels of miR-122 might be useful as disease parameter in patients with chronic hepatitis C virus (HCV) infection.

Citation

Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. 2011, 106 (9):1663-9 Am. J. Gastroenterol.

Affiliation

Department of Medicine I, University of Frankfurt/M., Frankfurt, Germany.

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Article

Language

ISSN

1572-0241

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publications of the research group drug design and optimization(HIPS]DDOP)

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