Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection.

Bihrer, Verena; Friedrich-Rust, Mireen; Kronenberger, Bernd; Forestier, Nicole; Haupenthal, Jörg; Shi, Ying; Peveling-Oberhag, Jan; Radeke, Heinfried H; Sarrazin, Christoph; Herrmann, Eva; Zeuzem, Stefan; Waidmann, Oliver; Piiper, Albrecht

dc.contributor.author	Bihrer, Verena
dc.contributor.author	Friedrich-Rust, Mireen
dc.contributor.author	Kronenberger, Bernd
dc.contributor.author	Forestier, Nicole
dc.contributor.author	Haupenthal, Jörg
dc.contributor.author	Shi, Ying
dc.contributor.author	Peveling-Oberhag, Jan
dc.contributor.author	Radeke, Heinfried H
dc.contributor.author	Sarrazin, Christoph
dc.contributor.author	Herrmann, Eva
dc.contributor.author	Zeuzem, Stefan
dc.contributor.author	Waidmann, Oliver
dc.contributor.author	Piiper, Albrecht
dc.date.accessioned	2012-03-05T14:52:18Z
dc.date.available	2012-03-05T14:52:18Z
dc.date.issued	2011-09
dc.identifier.citation	Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. 2011, 106 (9):1663-9 Am. J. Gastroenterol.	en
dc.identifier.issn	1572-0241
dc.identifier.pmid	21606975
dc.identifier.doi	10.1038/ajg.2011.161
dc.identifier.uri	http://hdl.handle.net/10033/214238
dc.description.abstract	The liver contains large amounts of microRNA-122 (miR-122), whereas other tissues contain only marginal amounts of this miRNA. MicroRNAs have also been found to circulate in the blood in a cell-free form; their potential as readily accessible disease markers is currently evaluated. Here, we investigated if the serum levels of miR-122 might be useful as disease parameter in patients with chronic hepatitis C virus (HCV) infection.
dc.language.iso	en	en
dc.subject.mesh	Adult	en
dc.subject.mesh	Aged	en
dc.subject.mesh	Alanine Transaminase	en
dc.subject.mesh	Aspartate Aminotransferases	en
dc.subject.mesh	Bilirubin	en
dc.subject.mesh	Biological Markers	en
dc.subject.mesh	Female	en
dc.subject.mesh	Hepatitis C, Chronic	en
dc.subject.mesh	Humans	en
dc.subject.mesh	International Normalized Ratio	en
dc.subject.mesh	Liver	en
dc.subject.mesh	Male	en
dc.subject.mesh	MicroRNAs	en
dc.subject.mesh	Middle Aged	en
dc.subject.mesh	Necrosis	en
dc.subject.mesh	Serum Albumin	en
dc.title	Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection.	en
dc.type	Article	en
dc.contributor.department	Department of Medicine I, University of Frankfurt/M., Frankfurt, Germany.	en
dc.identifier.journal	The American journal of gastroenterology	en
refterms.dateFOA	2012-03-15T00:00:00Z
html.description.abstract	The liver contains large amounts of microRNA-122 (miR-122), whereas other tissues contain only marginal amounts of this miRNA. MicroRNAs have also been found to circulate in the blood in a cell-free form; their potential as readily accessible disease markers is currently evaluated. Here, we investigated if the serum levels of miR-122 might be useful as disease parameter in patients with chronic hepatitis C virus (HCV) infection.