The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.

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Authors
Kukita, Akiko
Kukita, Toshio
Nagata, Kengo
Teramachi, Junpei
Li, Yin-Ji
Yoshida, Hiroki
Miyamoto, Hiroshi
Gay, Steffen
Pessler, Frank
Shobuike, Takeo
Issue Date
2011-09

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Abstract
Since transcription factors expressed in osteoclasts are possible targets for regulation of bone destruction in bone disorders, we investigated the expression of the transcription factor FBI-1/OCZF/LRF (in humans, factor that binds to inducer of short transcripts of human immunodeficiency virus type 1; in rats, osteoclast-derived zinc finger; in mice, leukemia/lymphoma-related factor) in patients with rheumatoid arthritis (RA), and assessed its role in osteoclastogenesis in vivo.
Citation
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. 2011, 63 (9):2744-54 Arthritis Rheum.
Affiliation
Department of Microbiology, Faculty of Medicine, Saga University, Saga, Japan. kukita@cc.saga-u.ac.jp
Journal
Arthritis and rheumatism
URI
http://hdl.handle.net/10033/214592
DOI
10.1002/art.30455
PubMed ID
21590684
Type
Article
Language
en
ISSN
1529-0131
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