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    Serum response factor contributes selectively to lymphocyte development.

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    Authors
    Fleige, Anne
    Alberti, Siegfried
    Gröbe, Lothar
    Frischmann, Ursula
    Geffers, Robert
    Müller, Werner
    Nordheim, Alfred
    Schippers, Angela
    Issue Date
    2007-08-17
    
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    Abstract
    Serum response factor (SRF), is a crucial transcription factor for murine embryonic development and for the function of muscle cells and neurons. Gene expression data show that SRF and its transcriptional cofactors are also expressed in lymphocyte precursors and mature lymphocytes. However, the role of SRF in lymphocyte development has not been addressed in vivo so far, attributed in part to early embryonic lethality of conventional Srf-null mice. To determine the in vivo role of SRF in developing lymphocytes, we specifically inactivated the murine Srf gene during T or B cell development using lymphocyte-specific Cre transgenic mouse lines. T cell-specific Srf deletion led to a severe block in thymocyte development at the transition from CD4/CD8 double to single positive stage. The few residual T cells detectable in the periphery retained at least one functional Srf allele, thereby demonstrating the importance of SRF in T cell development. In contrast, deletion of Srf in developing B cells did not interfere with the growth and survival of B cells in general, yet led to a complete loss of marginal zone B cells and a marked reduction of the CD5+ B cell subset. Our study also revealed a contribution of SRF to the expression of the surface molecules IgM, CD19, and the chemokine receptor 4 in B lymphocytes. We conclude that SRF fulfills essential and distinct functions in the differentiation of different types of lymphocytes.
    Citation
    Serum response factor contributes selectively to lymphocyte development. 2007, 282 (33):24320-8 J. Biol. Chem.
    Affiliation
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
    Journal
    The Journal of biological chemistry
    URI
    http://hdl.handle.net/10033/22173
    DOI
    10.1074/jbc.M703119200
    PubMed ID
    17591768
    Type
    Article
    Language
    en
    ISSN
    0021-9258
    ae974a485f413a2113503eed53cd6c53
    10.1074/jbc.M703119200
    Scopus Count
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    Publications of Dept. Experimental Immunology (EI)

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