Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication.

Chhatwal, Patrick; Bankwitz, Dorothea; Gentzsch, Juliane; Frentzen, Anne; Schult, Philipp; Lohmann, Volker; Pietschmann, Thomas

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Authors

Chhatwal, Patrick
Bankwitz, Dorothea
Gentzsch, Juliane
Frentzen, Anne
Schult, Philipp
Lohmann, Volker
Pietschmann, Thomas

Issue Date

2012

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Abstract

Hepatitis C virus (HCV) patients with high serum levels of bile acids (BAs) respond poorly to IFN therapy. BAs have been shown to increase RNA-replication of genotype 1 but not genotype 2a replicons. Since BAs modulate lipid metabolism including lipoprotein secretion and as HCV depends on lipids and lipoproteins during RNA-replication, virus production and cell entry, BAs may affect multiple steps of the HCV life cycle. Therefore, we analyzed the influence of BAs on individual steps of virus replication.

Citation

Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication. 2012, 7 (4):e36029 PLoS ONE

Affiliation

Department of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.

Type

Article

Language

ISSN

1932-6203

Collections

publications of the work group experimental Virology([TC]EVIR)

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