Kinome analysis of receptor-induced phosphorylation in human natural killer cells.
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Authors
König, SebastianNimtz, Manfred
Scheiter, Maxi
Ljunggren, Hans-Gustaf
Bryceson, Yenan T
Jänsch, Lothar

Issue Date
2012
Metadata
Show full item recordAbstract
Natural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.Citation
Kinome analysis of receptor-induced phosphorylation in human natural killer cells. 2012, 7 (1):e29672 PLoS ONEAffiliation
Department of Molecular Structural Biology, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.Journal
PloS onePubMed ID
22238634Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0029672
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