Kinome analysis of receptor-induced phosphorylation in human natural killer cells.

König, Sebastian; Nimtz, Manfred; Scheiter, Maxi; Ljunggren, Hans-Gustaf; Bryceson, Yenan T; Jänsch, Lothar

dc.contributor.author	König, Sebastian
dc.contributor.author	Nimtz, Manfred
dc.contributor.author	Scheiter, Maxi
dc.contributor.author	Ljunggren, Hans-Gustaf
dc.contributor.author	Bryceson, Yenan T
dc.contributor.author	Jänsch, Lothar
dc.date.accessioned	2012-06-06T14:18:27Z	en
dc.date.available	2012-06-06T14:18:27Z	en
dc.date.issued	2012	en
dc.identifier.citation	Kinome analysis of receptor-induced phosphorylation in human natural killer cells. 2012, 7 (1):e29672 PLoS ONE	en_GB
dc.identifier.issn	1932-6203	en
dc.identifier.pmid	22238634	en
dc.identifier.doi	10.1371/journal.pone.0029672	en
dc.identifier.uri	http://hdl.handle.net/10033/227676	en
dc.description.abstract	Natural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.
dc.language.iso	en	en
dc.rights	Archived with thanks to PloS one	en_GB
dc.subject.mesh	Amino Acid Sequence	en_GB
dc.subject.mesh	Animals	en_GB
dc.subject.mesh	Cells, Cultured	en_GB
dc.subject.mesh	Cluster Analysis	en_GB
dc.subject.mesh	Humans	en_GB
dc.subject.mesh	K562 Cells	en_GB
dc.subject.mesh	Killer Cells, Natural	en_GB
dc.subject.mesh	Mice	en_GB
dc.subject.mesh	Models, Biological	en_GB
dc.subject.mesh	Phosphoproteins	en_GB
dc.subject.mesh	Phosphorylation	en_GB
dc.subject.mesh	Phosphotransferases	en_GB
dc.subject.mesh	Phylogeny	en_GB
dc.subject.mesh	Primary Cell Culture	en_GB
dc.subject.mesh	Proteome	en_GB
dc.subject.mesh	Receptors, Cell Surface	en_GB
dc.subject.mesh	Receptors, Fc	en_GB
dc.title	Kinome analysis of receptor-induced phosphorylation in human natural killer cells.	en
dc.type	Article	en
dc.contributor.department	Department of Molecular Structural Biology, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.	en_GB
dc.identifier.journal	PloS one	en_GB
refterms.dateFOA	2018-06-13T05:29:27Z
html.description.abstract	Natural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.