Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.

Centanni, Manuela; Bergmann, Simone; Turroni, Silvia; Hammerschmidt, Sven; Chhatwal, Gursharan Singh; Brigidi, Patrizia; Candela, Marco

dc.contributor.author	Centanni, Manuela
dc.contributor.author	Bergmann, Simone
dc.contributor.author	Turroni, Silvia
dc.contributor.author	Hammerschmidt, Sven
dc.contributor.author	Chhatwal, Gursharan Singh
dc.contributor.author	Brigidi, Patrizia
dc.contributor.author	Candela, Marco
dc.date.accessioned	2012-07-13T09:12:54Z
dc.date.available	2012-07-13T09:12:54Z
dc.date.issued	2012-04
dc.identifier.citation	Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. 2012, 78 (7):2465-9 Appl. Environ. Microbiol.	en_GB
dc.identifier.issn	1098-5336
dc.identifier.pmid	22287006
dc.identifier.doi	10.1128/AEM.07883-11
dc.identifier.uri	http://hdl.handle.net/10033/233551
dc.description.abstract	The capacity to intervene with the host plasminogen system has recently been considered an important component in the interaction process between Bifidobacterium animalis subsp. lactis and the human host. However, its significance in the bifidobacterial microecology within the human gastrointestinal tract is still an open question. Here we demonstrate that human plasminogen favors the B. animalis subsp. lactis BI07 adhesion to HT29 cells. Prompting the HT29 cell capacity to activate plasminogen, tumor necrosis factor alpha (TNF-α) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.
dc.language.iso	en	en
dc.rights	Archived with thanks to Applied and environmental microbiology	en_GB
dc.title	Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes.	en
dc.type	Article	en
dc.contributor.department	Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.	en_GB
dc.identifier.journal	Applied and environmental microbiology	en_GB
refterms.dateFOA	2018-06-13T15:12:37Z
html.description.abstract	The capacity to intervene with the host plasminogen system has recently been considered an important component in the interaction process between Bifidobacterium animalis subsp. lactis and the human host. However, its significance in the bifidobacterial microecology within the human gastrointestinal tract is still an open question. Here we demonstrate that human plasminogen favors the B. animalis subsp. lactis BI07 adhesion to HT29 cells. Prompting the HT29 cell capacity to activate plasminogen, tumor necrosis factor alpha (TNF-α) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.