TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
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Authors
Warnecke, NicolePoltorak, Mateusz
Kowtharapu, Bhavani S
Arndt, Boerge
Stone, James C
Schraven, Burkhart
Simeoni, Luca
Issue Date
2012-04
Metadata
Show full item recordAbstract
Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. Conversely, Grb2/Sos—but not RasGRP1—are required for IL2-mediated Erk activation. Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR.Citation
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. 2012, 13 (4):386-91 EMBO Rep.Affiliation
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg 39120, Germany.Journal
EMBO reportsPubMed ID
22344067Type
ArticleLanguage
enISSN
1469-3178ae974a485f413a2113503eed53cd6c53
10.1038/embor.2012.17
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