Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures.
dc.contributor.author | Alberts, Rudi | |
dc.contributor.author | Lu, Lu | |
dc.contributor.author | Williams, Robert W | |
dc.contributor.author | Schughart, Klaus | |
dc.date.accessioned | 2012-07-27T12:11:15Z | en |
dc.date.available | 2012-07-27T12:11:15Z | en |
dc.date.issued | 2011 | en |
dc.identifier.citation | Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. 2011, 12:61 Respir. Res. | en_GB |
dc.identifier.issn | 1465-993X | en |
dc.identifier.pmid | 21535883 | en |
dc.identifier.doi | 10.1186/1465-9921-12-61 | en |
dc.identifier.uri | http://hdl.handle.net/10033/235971 | en |
dc.description.abstract | The lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative lung gene expression levels in inbred mouse strains and a large family of BXD strains that are widely used for systems genetics. Our goal is to provide a key community resource on the genetics of the normative lung transcriptome that can serve as a foundation for experimental analysis and allow predicting genetic predisposition and response to pathogens, allergens, and xenobiotics. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Respiratory research | en_GB |
dc.subject.mesh | Animals | en_GB |
dc.subject.mesh | B-Lymphocytes | en_GB |
dc.subject.mesh | Female | en_GB |
dc.subject.mesh | Gene Expression Profiling | en_GB |
dc.subject.mesh | Gene Expression Regulation | en_GB |
dc.subject.mesh | Gene Regulatory Networks | en_GB |
dc.subject.mesh | Genetic Predisposition to Disease | en_GB |
dc.subject.mesh | Heredity | en_GB |
dc.subject.mesh | Lod Score | en_GB |
dc.subject.mesh | Lung | en_GB |
dc.subject.mesh | Male | en_GB |
dc.subject.mesh | Mice | en_GB |
dc.subject.mesh | Mice, Inbred BALB C | en_GB |
dc.subject.mesh | Mice, Inbred C57BL | en_GB |
dc.subject.mesh | Mice, Inbred DBA | en_GB |
dc.subject.mesh | Oligonucleotide Array Sequence Analysis | en_GB |
dc.subject.mesh | Phenotype | en_GB |
dc.subject.mesh | Quantitative Trait, Heritable | en_GB |
dc.subject.mesh | RNA, Messenger | en_GB |
dc.subject.mesh | Species Specificity | en_GB |
dc.subject.mesh | T-Lymphocytes | en_GB |
dc.title | Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures. | en |
dc.type | Article | en |
dc.contributor.department | Department of Infection Genetics, University of Veterinary Medicine Hannover, Inhoffenstr, Braunschweig, Germany. | en_GB |
dc.identifier.journal | Respiratory research | en_GB |
refterms.dateFOA | 2018-06-13T03:46:41Z | |
html.description.abstract | The lung is critical in surveillance and initial defense against pathogens. In humans, as in mice, individual genetic differences strongly modulate pulmonary responses to infectious agents, severity of lung disease, and potential allergic reactions. In a first step towards understanding genetic predisposition and pulmonary molecular networks that underlie individual differences in disease vulnerability, we performed a global analysis of normative lung gene expression levels in inbred mouse strains and a large family of BXD strains that are widely used for systems genetics. Our goal is to provide a key community resource on the genetics of the normative lung transcriptome that can serve as a foundation for experimental analysis and allow predicting genetic predisposition and response to pathogens, allergens, and xenobiotics. |