Show simple item record

dc.contributor.authorGöhler, Anna-Katharina
dc.contributor.authorKökpinar, Öznur
dc.contributor.authorSchmidt-Heck, Wolfgang
dc.contributor.authorGeffers, Robert
dc.contributor.authorGuthke, Reinhard
dc.contributor.authorRinas, Ursula
dc.contributor.authorSchuster, Stefan
dc.contributor.authorJahreis, Knut
dc.contributor.authorKaleta, Christoph
dc.date.accessioned2012-08-02T10:34:07Z
dc.date.available2012-08-02T10:34:07Z
dc.date.issued2011
dc.identifier.citationMore than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biolen_GB
dc.identifier.issn1752-0509
dc.identifier.pmid22168595
dc.identifier.doi10.1186/1752-0509-5-197
dc.identifier.urihttp://hdl.handle.net/10033/236989
dc.description.abstractThe pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach.
dc.language.isoenen
dc.rightsArchived with thanks to BMC systems biologyen_GB
dc.subject.meshEscherichia colien_GB
dc.subject.meshEscherichia coli Proteinsen_GB
dc.subject.meshGene Expression Regulation, Bacterialen_GB
dc.subject.meshGene Regulatory Networksen_GB
dc.subject.meshGenes, Bacterialen_GB
dc.subject.meshMetabolic Networks and Pathwaysen_GB
dc.subject.meshRegulonen_GB
dc.subject.meshRepressor Proteinsen_GB
dc.subject.meshSystems Biologyen_GB
dc.titleMore than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.en
dc.typeArticleen
dc.contributor.departmentDepartment of Genetics, University of Osnabrück, Osnabrück, Germany.en_GB
dc.identifier.journalBMC systems biologyen_GB
refterms.dateFOA2018-06-13T20:02:18Z
html.description.abstractThe pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach.


Files in this item

Thumbnail
Name:
göhler-kökpinar et al_final.pdf
Size:
1.338Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record