More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.
dc.contributor.author | Göhler, Anna-Katharina | |
dc.contributor.author | Kökpinar, Öznur | |
dc.contributor.author | Schmidt-Heck, Wolfgang | |
dc.contributor.author | Geffers, Robert | |
dc.contributor.author | Guthke, Reinhard | |
dc.contributor.author | Rinas, Ursula | |
dc.contributor.author | Schuster, Stefan | |
dc.contributor.author | Jahreis, Knut | |
dc.contributor.author | Kaleta, Christoph | |
dc.date.accessioned | 2012-08-02T10:34:07Z | |
dc.date.available | 2012-08-02T10:34:07Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biol | en_GB |
dc.identifier.issn | 1752-0509 | |
dc.identifier.pmid | 22168595 | |
dc.identifier.doi | 10.1186/1752-0509-5-197 | |
dc.identifier.uri | http://hdl.handle.net/10033/236989 | |
dc.description.abstract | The pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to BMC systems biology | en_GB |
dc.subject.mesh | Escherichia coli | en_GB |
dc.subject.mesh | Escherichia coli Proteins | en_GB |
dc.subject.mesh | Gene Expression Regulation, Bacterial | en_GB |
dc.subject.mesh | Gene Regulatory Networks | en_GB |
dc.subject.mesh | Genes, Bacterial | en_GB |
dc.subject.mesh | Metabolic Networks and Pathways | en_GB |
dc.subject.mesh | Regulon | en_GB |
dc.subject.mesh | Repressor Proteins | en_GB |
dc.subject.mesh | Systems Biology | en_GB |
dc.title | More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. | en |
dc.type | Article | en |
dc.contributor.department | Department of Genetics, University of Osnabrück, Osnabrück, Germany. | en_GB |
dc.identifier.journal | BMC systems biology | en_GB |
refterms.dateFOA | 2018-06-13T20:02:18Z | |
html.description.abstract | The pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach. |