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Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.

dc.contributor.authorBihrer, Verena
dc.contributor.authorWaidmann, Oliver
dc.contributor.authorFriedrich-Rust, Mireen
dc.contributor.authorForestier, Nicole
dc.contributor.authorSusser, Simone
dc.contributor.authorHaupenthal, Jörg
dc.contributor.authorWelker, Martin
dc.contributor.authorShi, Ying
dc.contributor.authorPeveling-Oberhag, Jan
dc.contributor.authorPolta, Andreas
dc.contributor.authorvon Wagner, Michael
dc.contributor.authorRadeke, Heinfried H
dc.contributor.authorSarrazin, Christoph
dc.contributor.authorTrojan, Jörg
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorKronenberger, Bernd
dc.contributor.authorPiiper, Albrecht
dc.date.accessioned2012-08-03T12:25:14Z
dc.date.available2012-08-03T12:25:14Z
dc.date.issued2011
dc.identifier.citationSerum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. 2011, 6 (10):e26971 PLoS ONEen_GB
dc.identifier.issn1932-6203
dc.identifier.pmid22066022
dc.identifier.doi10.1371/journal.pone.0026971
dc.identifier.urihttp://hdl.handle.net/10033/237153
dc.description.abstractMicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.subject.meshAlanine Transaminaseen_GB
dc.subject.meshAspartate Aminotransferasesen_GB
dc.subject.meshBilirubinen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshCarcinoma, Hepatocellularen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHepatitis C, Chronicen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInflammationen_GB
dc.subject.meshLiver Neoplasmsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMicroRNAsen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMultivariate Analysisen_GB
dc.subject.meshNecrosisen_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshSerum Albuminen_GB
dc.subject.meshgamma-Glutamyltransferaseen_GB
dc.titleSerum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine I, University of Frankfurt/M., Frankfurt, Germany.en_GB
dc.identifier.journalPloS oneen_GB
refterms.dateFOA2018-06-13T03:46:56Z
html.description.abstractMicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.


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