Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.

Ebrahim, Weaam; Kjer, Julia; El Amrani, Mustapha; Wray, Victor; Lin, Wenhan; Ebel, Rainer; Lai, Daowan; Proksch, Peter

dc.contributor.author	Ebrahim, Weaam
dc.contributor.author	Kjer, Julia
dc.contributor.author	El Amrani, Mustapha
dc.contributor.author	Wray, Victor
dc.contributor.author	Lin, Wenhan
dc.contributor.author	Ebel, Rainer
dc.contributor.author	Lai, Daowan
dc.contributor.author	Proksch, Peter
dc.date.accessioned	2012-08-22T13:01:10Z
dc.date.available	2012-08-22T13:01:10Z
dc.date.issued	2012-05
dc.identifier.citation	Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris. 2012, 10 (5):1081-91 Mar Drugs	en_GB
dc.identifier.issn	1660-3397
dc.identifier.pmid	22822358
dc.identifier.doi	10.3390/md10051081
dc.identifier.uri	http://hdl.handle.net/10033/239471
dc.description.abstract	Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL.
dc.language.iso	en	en
dc.rights	Archived with thanks to Marine drugs	en_GB
dc.title	Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.	en
dc.type	Article	en
dc.contributor.department	Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany; Email: weel-001@uni-duesseldorf.de or weaamnabil@mans.edu.eg (W.E.); jacob.julia@web.de (J.K.); mustapha.elamrani@uni-duesseldorf.de (M.E.A.).	en_GB
dc.identifier.journal	Marine drugs	en_GB
refterms.dateFOA	2018-06-13T15:56:03Z
html.description.abstract	Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL.