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dc.contributor.authorHeroven, Ann Kathrin
dc.contributor.authorBöhme, Katja
dc.contributor.authorDersch, Petra
dc.date.accessioned2012-10-02T08:21:07Z
dc.date.available2012-10-02T08:21:07Z
dc.date.issued2012-04-01
dc.identifier.citationThe Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence. 2012, 9 (4):notRNA Biolen_GB
dc.identifier.issn1555-8584
dc.identifier.pmid22336760
dc.identifier.urihttp://hdl.handle.net/10033/246492
dc.description.abstractThis review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.
dc.languageENG
dc.rightsArchived with thanks to RNA biologyen_GB
dc.titleThe Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence.
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Infection Biology; Helmholtz Centre for Infection Research; Braunschweig, Germany; These authors contributed equally to this work.en_GB
dc.identifier.journalRNA biologyen_GB
refterms.dateFOA2018-06-12T23:03:10Z
html.description.abstractThis review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.


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