Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Jones, Des C
Allen, Rachel L
MetadataShow full item record
AbstractLeukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have been identified in rodents, primates, seals and chickens. The murine equivalents, paired Ig-like receptors (PIR), contain two additional immunoglobulin domains, but show strong sequence and functional similarities to human LILR. The bovine genome was recently sequenced, with preliminary annotations indicating that LILR were present in this species. We therefore sought to identify and characterize novel LILR within the Bos taurus genome, compare these phylogenetically with LILR from other species and determine whether they were expressed in vivo. Twenty six potential bovine LILR were initially identified using BLAST and BLAT software. Phylogenetic analysis constructed using the neighbour-joining method, incorporating pairwise deletion and confidence limits estimated from 1000 replicates using bootstrapping, indicated that 16 of these represent novel bovine LILR. Protein structures defined using protein BLAST predict that the bovine LILR family comprises seven putative inhibitory, four activating and five soluble receptors. Preliminary expression analysis was performed by mapping the predicted sequences with raw data from total transcript sequence generated using Genome Analyzer IIx (Illumina) to provide evidence that all 16 of these receptors are expressed in vivo. The bovine receptor family appears to contain receptors which resemble the six domain rodent PIR as well as the four domain LILR found in other species.
CitationCharacterisation of bovine leukocyte Ig-like receptors. 2012, 7 (4):e34291 PLoS ONE
AffiliationCentre for Infection, Division of Clinical Sciences, St George's, University of London, Cranmer Terrace, London, United Kingdom. email@example.com
The following license files are associated with this item:
- The unique evolution of the pig LRC, a single KIR but expansion of LILR and a novel Ig receptor family.
- Authors: Schwartz JC, Hammond JA
- Issue date: 2018 Nov
- The Genomic Organization of the <i>LILR</i> Region Remained Largely Conserved Throughout Primate Evolution: Implications for Health And Disease.
- Authors: Storm L, Bruijnesteijn J, de Groot NG, Bontrop RE
- Issue date: 2021
- Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X.
- Authors: Welch AY, Kasahara M, Spain LM
- Issue date: 2003 Feb
- Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations.
- Authors: Hirayasu K, Arase H
- Issue date: 2015 Nov
- The LILR family: modulators of innate and adaptive immune pathways in health and disease.
- Authors: Brown D, Trowsdale J, Allen R
- Issue date: 2004 Sep