Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Zainuddin, Elmi N; Mentel, Renate; Wray, Victor; Jansen, Rolf; Nimtz, Manfred; Lalk, Michael; Mundt, Sabine

dc.contributor.author	Zainuddin, Elmi N
dc.contributor.author	Mentel, Renate
dc.contributor.author	Wray, Victor
dc.contributor.author	Jansen, Rolf
dc.contributor.author	Nimtz, Manfred
dc.contributor.author	Lalk, Michael
dc.contributor.author	Mundt, Sabine
dc.date.accessioned	2008-05-06T13:13:23Z
dc.date.available	2008-05-06T13:13:23Z
dc.date.issued	2007-07
dc.identifier.citation	Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. 2007, 70 (7):1084-8 J. Nat. Prod.	en
dc.identifier.issn	0163-3864
dc.identifier.pmid	17602586
dc.identifier.doi	10.1021/np060303s
dc.identifier.uri	http://hdl.handle.net/10033/24872
dc.description.abstract	Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
dc.language.iso	en	en
dc.subject.mesh	Antiviral Agents	en
dc.subject.mesh	Depsipeptides	en
dc.subject.mesh	Germany	en
dc.subject.mesh	Influenza A virus	en
dc.subject.mesh	Inhibitory Concentration 50	en
dc.subject.mesh	Microcystis	en
dc.subject.mesh	Molecular Structure	en
dc.subject.mesh	Nuclear Magnetic Resonance, Biomolecular	en
dc.title	Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.	en
dc.type	Article	en
dc.contributor.department	Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.	en
dc.identifier.journal	Journal of natural products	en
refterms.dateFOA	2008-07-05T00:00:00Z
html.description.abstract	Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.