Show simple item record

dc.contributor.authorZainuddin, Elmi N
dc.contributor.authorMentel, Renate
dc.contributor.authorWray, Victor
dc.contributor.authorJansen, Rolf
dc.contributor.authorNimtz, Manfred
dc.contributor.authorLalk, Michael
dc.contributor.authorMundt, Sabine
dc.date.accessioned2008-05-06T13:13:23Z
dc.date.available2008-05-06T13:13:23Z
dc.date.issued2007-07
dc.identifier.citationCyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. 2007, 70 (7):1084-8 J. Nat. Prod.en
dc.identifier.issn0163-3864
dc.identifier.pmid17602586
dc.identifier.doi10.1021/np060303s
dc.identifier.urihttp://hdl.handle.net/10033/24872
dc.description.abstractBioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
dc.language.isoenen
dc.subject.meshAntiviral Agentsen
dc.subject.meshDepsipeptidesen
dc.subject.meshGermanyen
dc.subject.meshInfluenza A virusen
dc.subject.meshInhibitory Concentration 50en
dc.subject.meshMicrocystisen
dc.subject.meshMolecular Structureen
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen
dc.titleCyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.en
dc.typeArticleen
dc.contributor.departmentInstitute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.en
dc.identifier.journalJournal of natural productsen
refterms.dateFOA2008-07-05T00:00:00Z
html.description.abstractBioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.


Files in this item

Thumbnail
Name:
Zainuddin_final.pdf
Size:
224.6Kb
Format:
PDF
Description:
original manuscript

This item appears in the following Collection(s)

Show simple item record