Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractAn infection represents a highly dynamic process involving complex biological responses of the host at many levels. To describe such processes at a global level, we recorded gene expression changes in mouse lungs after a non-lethal infection with influenza A virus over a period of 60 days. Global analysis of the large data set identified distinct phases of the host response. The increase in interferon genes and up-regulation of a defined NK-specific gene set revealed the initiation of the early innate immune response phase. Subsequently, infiltration and activation of T and B cells could be observed by an augmentation of T and B cell specific signature gene expression. The changes in B cell gene expression and preceding chemokine subsets were associated with the formation of bronchus-associated lymphoid tissue. In addition, we compared the gene expression profiles from wild type mice with Rag2 mutant mice. This analysis readily demonstrated that the deficiency in the T and B cell responses in Rag2 mutants could be detected by changes in the global gene expression patterns of the whole lung. In conclusion, our comprehensive gene expression study describes for the first time the entire host response and its kinetics to an acute influenza A infection at the transcriptome level.
CitationGlobal transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses. 2012, 7 (7):e41169 PLoS ONE
AffiliationDepartment of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Braunschweig, Germany.
The following license files are associated with this item:
- Impaired immune responses in the lungs of aged mice following influenza infection.
- Authors: Toapanta FR, Ross TM
- Issue date: 2009 Nov 18
- Initial infectious dose dictates the innate, adaptive, and memory responses to influenza in the respiratory tract.
- Authors: Marois I, Cloutier A, Garneau É, Richter MV
- Issue date: 2012 Jul
- Innate Immunity Induces the Accumulation of Lung Mast Cells During Influenza Infection.
- Authors: Zarnegar B, Westin A, Evangelidou S, Hallgren J
- Issue date: 2018
- CD47 Plays a Role as a Negative Regulator in Inducing Protective Immune Responses to Vaccination against Influenza Virus.
- Authors: Lee YT, Ko EJ, Lee Y, Lee YN, Bian Z, Liu Y, Kang SM
- Issue date: 2016 Aug 1
- Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.
- Authors: Rai KR, Chen B, Zhao Z, Chen Y, Hu J, Liu S, Maarouf M, Li Y, Xiao M, Liao Y, Chen JL
- Issue date: 2020 Nov