Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells.
Name:
Van der Vlugt_final.pdf
Size:
622.8Kb
Format:
PDF
Description:
Open Access publication
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
van der Vlugt, Luciën E P MLabuda, Lucja A
Ozir-Fazalalikhan, Arifa
Lievers, Ellen
Gloudemans, Anouk K
Liu, Kit-Yeng
Barr, Tom A
Sparwasser, Tim
Boon, Louis
Ngoa, Ulysse Ateba
Feugap, Eliane Ngoune
Adegnika, Ayola A
Kremsner, Peter G
Gray, David
Yazdanbakhsh, Maria
Smits, Hermelijn H
Issue Date
2012
Metadata
Show full item recordAbstract
Chronic helminth infections, such as schistosomes, are negatively associated with allergic disorders. Here, using B cell IL-10-deficient mice, Schistosoma mansoni-mediated protection against experimental ovalbumin-induced allergic airway inflammation (AAI) was shown to be specifically dependent on IL-10-producing B cells. To study the organs involved, we transferred B cells from lungs, mesenteric lymph nodes or spleen of OVA-infected mice to recipient OVA-sensitized mice, and showed that both lung and splenic B cells reduced AAI, but only splenic B cells in an IL-10-dependent manner. Although splenic B cell protection was accompanied by elevated levels of pulmonary FoxP3(+) regulatory T cells, in vivo ablation of FoxP3(+) T cells only moderately restored AAI, indicating an important role for the direct suppressory effect of regulatory B cells. Splenic marginal zone CD1d(+) B cells proved to be the responsible splenic B cell subset as they produced high levels of IL-10 and induced FoxP3(+) T cells in vitro. Indeed, transfer of CD1d(+) MZ-depleted splenic B cells from infected mice restored AAI. Markedly, we found a similarly elevated population of CD1d(hi) B cells in peripheral blood of Schistosoma haematobium-infected Gabonese children compared to uninfected children and these cells produced elevated levels of IL-10. Importantly, the number of IL-10-producing CD1d(hi) B cells was reduced after anti-schistosome treatment. This study points out that in both mice and men schistosomes have the capacity to drive the development of IL-10-producing regulatory CD1d(hi) B cells and furthermore, these are instrumental in reducing experimental allergic inflammation in mice.Citation
Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. 2012, 7 (2):e30883 PLoS ONEAffiliation
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.Journal
PloS onePubMed ID
22347409Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0030883
Scopus Count
The following license files are associated with this item:
Related articles
- Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
- Authors: Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG
- Issue date: 2015 Jun
- Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
- Authors: Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG
- Issue date: 2010 May
- Interleukin 10 (IL-10)-producing CD1dhi regulatory B cells from Schistosoma haematobium-infected individuals induce IL-10-positive T cells and suppress effector T-cell cytokines.
- Authors: van der Vlugt LE, Zinsou JF, Ozir-Fazalalikhan A, Kremsner PG, Yazdanbakhsh M, Adegnika AA, Smits HH
- Issue date: 2014 Oct 15
- Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation.
- Authors: Gao X, Ren X, Wang Q, Yang Z, Li Y, Su Z, Li J
- Issue date: 2019 Dec
- B-cell-specific-peroxisome proliferator-activated receptor γ deficiency augments contact hypersensitivity with impaired regulatory B cells.
- Authors: Su J, Wang K, Zhou X, Wang Y, Xu J, Tao L, Zeng X, Chen N, Bai X, Li X
- Issue date: 2019 Mar