Show simple item record

dc.contributor.authorRueckert, Christine
dc.contributor.authorGuzmán, Carlos A
dc.date.accessioned2012-12-11T15:38:47Z
dc.date.available2012-12-11T15:38:47Z
dc.date.issued2012-11
dc.identifier.citationVaccines: from empirical development to rational design. 2012, 8 (11):e1003001 PLoS Pathog.en_GB
dc.identifier.issn1553-7374
dc.identifier.pmid23144616
dc.identifier.doi10.1371/journal.ppat.1003001
dc.identifier.urihttp://hdl.handle.net/10033/255243
dc.description.abstractInfectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.
dc.language.isoenen
dc.rightsArchived with thanks to PLoS pathogensen_GB
dc.titleVaccines: from empirical development to rational design.en
dc.typeArticleen
dc.contributor.departmentDepartment of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en_GB
dc.identifier.journalPLoS pathogensen_GB
refterms.dateFOA2018-06-13T02:40:10Z
html.description.abstractInfectious diseases are responsible for an overwhelming number of deaths worldwide and their clinical management is often hampered by the emergence of multi-drug-resistant strains. Therefore, prevention through vaccination currently represents the best course of action to combat them. However, immune escape and evasion by pathogens often render vaccine development difficult. Furthermore, most currently available vaccines were empirically designed. In this review, we discuss why rational design of vaccines is not only desirable but also necessary. We introduce recent developments towards specifically tailored antigens, adjuvants, and delivery systems, and discuss the methodological gaps and lack of knowledge still hampering true rational vaccine design. Finally, we address the potential and limitations of different strategies and technologies for advancing vaccine development.


Files in this item

Thumbnail
Name:
Rueckert and Guzman_final.pdf
Size:
395.0Kb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record