Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Bills, Gerald FGonzález-Menéndez, Victor
Martín, Jesús
Platas, Gonzalo
Fournier, Jacques
Peršoh, Derek
Stadler, Marc
Issue Date
2012
Metadata
Show full item recordAbstract
Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.Citation
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. 2012, 7 (10):e46687 PLoS ONEAffiliation
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain. gerald.bills@medinaandalucia.esJournal
PloS onePubMed ID
23056404Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0046687
Scopus Count
The following license files are associated with this item:
Related articles
- An endophytic Nodulisporium sp. from Central America producing volatile organic compounds with both biological and fuel potential.
- Authors: Riyaz-Ul-Hassan S, Strobel G, Geary B, Sears J
- Issue date: 2013 Jan
- Diversity of biologically active secondary metabolites from endophytic and saprotrophic fungi of the ascomycete order Xylariales.
- Authors: Helaly SE, Thongbai B, Stadler M
- Issue date: 2018 Sep 19
- Molecular phylogeny of Hypoxylon and closely related genera.
- Authors: Hsieh HM, Ju YM, Rogers JD
- Issue date: 2005 Jul-Aug
- Observations on Texas hypoxylons, including two new Hypoxylon species and widespread environmental isolates of the H. croceum complex identified by a polyphasic approach.
- Authors: Sir EB, Becker K, Lambert C, Bills GF, Kuhnert E
- Issue date: 2019 Sep-Oct
- Functionalized para-substituted benzenes as 1,8-cineole production modulators in an endophytic Nodulisporium species.
- Authors: Nigg J, Strobel G, Knighton WB, Hilmer J, Geary B, Riyaz-Ul-Hassan S, Harper JK, Valenti D, Wang Y
- Issue date: 2014 Aug