Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.

Bills, Gerald F; González-Menéndez, Victor; Martín, Jesús; Platas, Gonzalo; Fournier, Jacques; Peršoh, Derek; Stadler, Marc

dc.contributor.author	Bills, Gerald F
dc.contributor.author	González-Menéndez, Victor
dc.contributor.author	Martín, Jesús
dc.contributor.author	Platas, Gonzalo
dc.contributor.author	Fournier, Jacques
dc.contributor.author	Peršoh, Derek
dc.contributor.author	Stadler, Marc
dc.date.accessioned	2013-01-17T15:22:27Z	en
dc.date.available	2013-01-17T15:22:27Z	en
dc.date.issued	2012	en
dc.identifier.citation	Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte. 2012, 7 (10):e46687 PLoS ONE	en_GB
dc.identifier.issn	1932-6203	en
dc.identifier.pmid	23056404	en
dc.identifier.doi	10.1371/journal.pone.0046687	en
dc.identifier.uri	http://hdl.handle.net/10033/265912	en
dc.description.abstract	Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.
dc.language.iso	en	en
dc.rights	Archived with thanks to PloS one	en_GB
dc.title	Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.	en
dc.type	Article	en
dc.contributor.department	Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain. gerald.bills@medinaandalucia.es	en_GB
dc.identifier.journal	PloS one	en_GB
refterms.dateFOA	2018-06-12T20:05:57Z
html.description.abstract	Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species.