The expanding world of extracellular traps: not only neutrophils but much more.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe release of extracellular traps (ETs) is a recently described mechanism of innate immune response to infection. Although ETs have been intensely investigated in the context of neutrophil antimicrobial effector mechanisms, other immune cells such as mast cells, eosinophils, and macrophages can also release these structures. The different ETs have several features in common, regardless of the type of cells from which they originated, including a DNA backbone with embedded antimicrobial peptides, proteases, and histones. However, they also exhibit remarkable individual differences such as the type of sub-cellular compartments from where the DNA backbone originates (e.g., nucleus or mitochondria), the proportion of responding cells within the pool, and/or the molecular mechanism/s underlying the ETs formation. This review summarizes the knowledge accumulated in recent years regarding the complex and expanding world of ETs and their role in immune function with particular emphasis on the role of other immune cells rather than on neutrophils exclusively.
CitationThe expanding world of extracellular traps: not only neutrophils but much more. 2012, 3:420 Front Immunol
AffiliationInfection Immunology Research Group, Helmholtz Centre for Infection Research Braunschweig, Germany.
JournalFrontiers in immunology
The following license files are associated with this item:
- The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.
- Authors: Conceição-Silva F, Reis CSM, De Luca PM, Leite-Silva J, Santiago MA, Morrot A, Morgado FN
- Issue date: 2021 Jul 26
- Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps.
- Authors: von Köckritz-Blickwede M, Nizet V
- Issue date: 2009 Aug
- Harbour seal (Phoca vitulina) PMN and monocytes release extracellular traps to capture the apicomplexan parasite Toxoplasma gondii.
- Authors: Reichel M, Muñoz-Caro T, Sanchez Contreras G, Rubio García A, Magdowski G, Gärtner U, Taubert A, Hermosilla C
- Issue date: 2015 Jun
- Platelets and extracellular traps in infections.
- Authors: Gómez RM, López Ortiz AO, Schattner M
- Issue date: 2021 Apr 3
- <i>Salmonella</i> Typhimurium Triggers Extracellular Traps Release in Murine Macrophages.
- Authors: Mónaco A, Canales-Huerta N, Jara-Wilde J, Härtel S, Chabalgoity JA, Moreno M, Scavone P
- Issue date: 2021