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dc.contributor.authorGoldmann, Oliver
dc.contributor.authorMedina, Eva
dc.date.accessioned2013-02-11T15:37:53Zen
dc.date.available2013-02-11T15:37:53Zen
dc.date.issued2012en
dc.identifier.citationThe expanding world of extracellular traps: not only neutrophils but much more. 2012, 3:420 Front Immunolen_GB
dc.identifier.issn1664-3224en
dc.identifier.pmid23335924en
dc.identifier.doi10.3389/fimmu.2012.00420en
dc.identifier.urihttp://hdl.handle.net/10033/269032en
dc.description.abstractThe release of extracellular traps (ETs) is a recently described mechanism of innate immune response to infection. Although ETs have been intensely investigated in the context of neutrophil antimicrobial effector mechanisms, other immune cells such as mast cells, eosinophils, and macrophages can also release these structures. The different ETs have several features in common, regardless of the type of cells from which they originated, including a DNA backbone with embedded antimicrobial peptides, proteases, and histones. However, they also exhibit remarkable individual differences such as the type of sub-cellular compartments from where the DNA backbone originates (e.g., nucleus or mitochondria), the proportion of responding cells within the pool, and/or the molecular mechanism/s underlying the ETs formation. This review summarizes the knowledge accumulated in recent years regarding the complex and expanding world of ETs and their role in immune function with particular emphasis on the role of other immune cells rather than on neutrophils exclusively.
dc.language.isoenen
dc.rightsArchived with thanks to Frontiers in immunologyen_GB
dc.titleThe expanding world of extracellular traps: not only neutrophils but much more.en
dc.typeArticleen
dc.contributor.departmentInfection Immunology Research Group, Helmholtz Centre for Infection Research Braunschweig, Germany.en_GB
dc.identifier.journalFrontiers in immunologyen_GB
refterms.dateFOA2018-06-13T19:33:20Z
html.description.abstractThe release of extracellular traps (ETs) is a recently described mechanism of innate immune response to infection. Although ETs have been intensely investigated in the context of neutrophil antimicrobial effector mechanisms, other immune cells such as mast cells, eosinophils, and macrophages can also release these structures. The different ETs have several features in common, regardless of the type of cells from which they originated, including a DNA backbone with embedded antimicrobial peptides, proteases, and histones. However, they also exhibit remarkable individual differences such as the type of sub-cellular compartments from where the DNA backbone originates (e.g., nucleus or mitochondria), the proportion of responding cells within the pool, and/or the molecular mechanism/s underlying the ETs formation. This review summarizes the knowledge accumulated in recent years regarding the complex and expanding world of ETs and their role in immune function with particular emphasis on the role of other immune cells rather than on neutrophils exclusively.


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