Efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.
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Müller, Peter Paul
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AbstractNanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
CitationEfficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits. 2013, 9 (1):4815-25 Acta Biomater
AffiliationDepartment of Otolaryngology, Hannover Medical School, Hannover, Germany. Lensing.Rebecca@mh-hannover.de
The following license files are associated with this item:
- Nanoporous silica coatings as a drug delivery system for ciprofloxacin: outcome of variable release rates in the infected middle ear of rabbits.
- Authors: Hesse D, Ehlert N, Lüenhop T, Smoczek A, Glage S, Behrens P, Müller PP, Esser KH, Lenarz T, Stieve M, Bleich A, Prenzler NK
- Issue date: 2013 Aug
- Biocompatibility of silver containing silica films on Bioverit® II middle ear prostheses in rabbits.
- Authors: Duda F, Bradel S, Bleich A, Abendroth P, Heemeier T, Ehlert N, Behrens P, Esser KH, Lenarz T, Brandes G, Prenzler NK
- Issue date: 2015 Jul
- Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the middle ear: an animal study in rabbits.
- Authors: Hesse D, Badar M, Bleich A, Smoczek A, Glage S, Kieke M, Behrens P, Müller PP, Esser KH, Stieve M, Prenzler NK
- Issue date: 2013 Jan
- Free Bioverit II implants coated with a nanoporous silica layer in a mouse ear model-- a histological study.
- Authors: Vogt JC, Brandes G, Ehlert N, Behrens P, Nolte I, Mueller PP, Lenarz T, Stieve M
- Issue date: 2009 Aug
- [Pretreatment before microsurgical interventions in the middle ear with reference to the current bacteriological and antibiotic situation].
- Authors: Luckhaupt H, Rose KG
- Issue date: 1983 Dec