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dc.contributor.authorLensing, Rebecca
dc.contributor.authorBleich, André
dc.contributor.authorSmoczek, Anna
dc.contributor.authorGlage, Silke
dc.contributor.authorEhlert, Nina
dc.contributor.authorLuessenhop, Tammo
dc.contributor.authorBehrens, Peter
dc.contributor.authorMüller, Peter Paul
dc.contributor.authorKietzmann, Manfred
dc.contributor.authorStieve, Martin
dc.date.accessioned2013-02-13T10:17:45Z
dc.date.available2013-02-13T10:17:45Z
dc.date.issued2013-01
dc.identifier.citationEfficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits. 2013, 9 (1):4815-25 Acta Biomateren_GB
dc.identifier.issn1878-7568
dc.identifier.pmid22906623
dc.identifier.doi10.1016/j.actbio.2012.08.016
dc.identifier.urihttp://hdl.handle.net/10033/269313
dc.description.abstractNanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.
dc.language.isoenen
dc.rightsArchived with thanks to Acta biomaterialiaen_GB
dc.titleEfficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics: an animal study in rabbits.en
dc.typeArticleen
dc.contributor.departmentDepartment of Otolaryngology, Hannover Medical School, Hannover, Germany. Lensing.Rebecca@mh-hannover.deen_GB
dc.identifier.journalActa biomaterialiaen_GB
refterms.dateFOA2018-06-12T23:27:02Z
html.description.abstractNanoporous silica layers are able to host molecules and release them over a certain period of time. These local drug delivery systems for antibiotics could be a new approach in the treatment of chronic otitis media. The aim of this study was to examine the efficacy of nanoporous silica coatings on middle ear prostheses as a delivery system for antibiotics in vivo. Pseudomonas aeruginosa was inoculated into the middle ear of rabbits to induce an otitis media. The control group received coated Bioverit®II implants without antibiotics. Coated prostheses with loaded ciprofloxacin were implanted into the middle ears of the study group. After 1 week, the rabbits were sacrificed. The clinical examination as well as the microbiological and histological examinations of organs and middle ear irrigation revealed clear differences between the two groups. P. aeruginosa was detected in every middle ear of the control group and was almost completely eliminated in the study group. Organ examinations revealed the presence of P. aeruginosa in the control group and a prevention of a bacterial spread in the study group. The nanoporous silica layer as antibiotic delivery system showed convincing efficacy in induced pseudomonal otitis media in the rabbit.


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