Show simple item record

dc.contributor.authorSteinmann, Rebekka
dc.contributor.authorDersch, Petra
dc.date.accessioned2013-02-19T13:41:17Z
dc.date.available2013-02-19T13:41:17Z
dc.date.issued2013-01
dc.identifier.citationThermosensing to adjust bacterial virulence in a fluctuating environment. 2013, 8:85-105 Future Microbiolen_GB
dc.identifier.issn1746-0921
dc.identifier.pmid23252495
dc.identifier.doi10.2217/fmb.12.129
dc.identifier.urihttp://hdl.handle.net/10033/269743
dc.description.abstractThe lifecycle of most microbial pathogens can be divided into two states: existence outside and inside their hosts. The sudden temperature upshift experienced upon entry from environmental or vector reservoirs into a warm-blooded host is one of the most crucial signals informing the pathogens to adjust virulence gene expression and their host-stress survival program. This article reviews the plethora of sophisticated strategies that bacteria have evolved to sense temperature, and outlines the molecular signal transduction mechanisms used to modulate synthesis of crucial virulence determinants. The molecular details of thermal control through conformational changes of DNA, RNA and proteins are summarized, complex and diverse thermosensing principles are introduced and their potential as drug targets or synthetic tools are discussed.
dc.language.isoenen
dc.rightsArchived with thanks to Future microbiologyen_GB
dc.titleThermosensing to adjust bacterial virulence in a fluctuating environment.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.en_GB
dc.identifier.journalFuture microbiologyen_GB
refterms.dateFOA2014-01-15T00:00:00Z
html.description.abstractThe lifecycle of most microbial pathogens can be divided into two states: existence outside and inside their hosts. The sudden temperature upshift experienced upon entry from environmental or vector reservoirs into a warm-blooded host is one of the most crucial signals informing the pathogens to adjust virulence gene expression and their host-stress survival program. This article reviews the plethora of sophisticated strategies that bacteria have evolved to sense temperature, and outlines the molecular signal transduction mechanisms used to modulate synthesis of crucial virulence determinants. The molecular details of thermal control through conformational changes of DNA, RNA and proteins are summarized, complex and diverse thermosensing principles are introduced and their potential as drug targets or synthetic tools are discussed.


Files in this item

Thumbnail
Name:
Steinmann_Dersch_final.pdf
Size:
1.088Mb
Format:
PDF
Description:
original manuscript

This item appears in the following Collection(s)

Show simple item record