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dc.contributor.authorHernandez-Vargas, Esteban A
dc.contributor.authorMiddleton, Richard H
dc.date.accessioned2013-04-15T12:48:28Z
dc.date.available2013-04-15T12:48:28Z
dc.date.issued2013-03-07
dc.identifier.citationModeling the three stages in HIV infection. 2013, 320:33-40 J. Theor. Biol.en_GB
dc.identifier.issn1095-8541
dc.identifier.pmid23238280
dc.identifier.doi10.1016/j.jtbi.2012.11.028
dc.identifier.urihttp://hdl.handle.net/10033/281312
dc.description.abstractA typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progression to AIDS. Simulation results illustrate how chronic infected macrophages can explain the progression to AIDS provoking viral explosion. Further simulation studies suggest that the proposed model retains its key properties even under moderately large parameter variations. This model provides important insights on how macrophages might play a crucial role in the long term behavior of HIV infection.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of theoretical biologyen_GB
dc.titleModeling the three stages in HIV infection.en
dc.typeArticleen
dc.contributor.departmentSIMM, Helmholtz Zentrum für Infektionsforschung, Inhoffenstraße 7, D-38124 Braunschweig, Germany.en_GB
dc.identifier.journalJournal of theoretical biologyen_GB
refterms.dateFOA2018-06-12T22:15:53Z
html.description.abstractA typical HIV infection response consists of three stages: an initial acute infection, a long asymptomatic period and a final increase in viral load with simultaneous collapse in healthy CD4+T cell counts. The majority of existing mathematical models give a good representation of either the first two stages or the last stage of the infection. Using macrophages as a long-term active reservoir, a deterministic model is proposed to explain the three stages of the infection including the progression to AIDS. Simulation results illustrate how chronic infected macrophages can explain the progression to AIDS provoking viral explosion. Further simulation studies suggest that the proposed model retains its key properties even under moderately large parameter variations. This model provides important insights on how macrophages might play a crucial role in the long term behavior of HIV infection.


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