Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe consumption of green tea (Camellia sinensis) has been shown to have many physiological and pharmacological health benefits. In the past two decades several studies have reported that epigallocatechin-3-gallate (EGCG), the main constituent of green tea, has anti-infective properties. Antiviral activities of EGCG with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. Furthermore, the molecule interferes with the replication cycle of DNA viruses like hepatitis B virus, herpes simplex virus and adenovirus. Most of these studies demonstrated antiviral properties within physiological concentrations of EGCG in vitro. In contrast, the minimum inhibitory concentrations against bacteria were 10-100-fold higher. Nevertheless, the antibacterial effects of EGCG alone and in combination with different antibiotics have been intensively analysed against a number of bacteria including multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus or Stenotrophomonas maltophilia. Furthermore, the catechin EGCG has antifungal activity against human-pathogenic yeasts like Candida albicans. Although the mechanistic effects of EGCG are not fully understood, there are results indicating that EGCG binds to lipid membranes and affects the folic acid metabolism of bacteria and fungi by inhibiting the cytoplasmic enzyme dihydrofolate reductase. This review summarizes the current knowledge and future perspectives on the antibacterial, antifungal and antiviral effects of the green tea constituent EGCG.
CitationAnti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. 2013, 168 (5):1059-73 Br. J. Pharmacol.
AffiliationInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. email@example.com
JournalBritish journal of pharmacology
The following license files are associated with this item:
- Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia.
- Authors: Gordon NC, Wareham DW
- Issue date: 2010 Aug
- Different susceptibilities of Staphylococcus and Gram-negative rods to epigallocatechin gallate.
- Authors: Yoda Y, Hu ZQ, Zhao WH, Shimamura T
- Issue date: 2004 Feb
- Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei.
- Authors: Morin MP, Bedran TB, Fournier-Larente J, Haas B, Azelmat J, Grenier D
- Issue date: 2015 Mar 10
- AFM study of the differential inhibitory effects of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against Gram-positive and Gram-negative bacteria.
- Authors: Cui Y, Oh YJ, Lim J, Youn M, Lee I, Pak HK, Park W, Jo W, Park S
- Issue date: 2012 Feb
- In vitro activity of 23 tea extractions and epigallocatechin gallate against Candida species.
- Authors: Chen M, Zhai L, Arendrup MC
- Issue date: 2015 Feb 1