Bacterial invasion factors: Tools for crossing biological barriers and drug delivery?
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe oral route is the preferential route of drug delivery in humans. However, effective delivery through the gastrointestinal tract is often hampered by the low permeability of the intestinal epithelium. One possibility to overcome this problem is the encapsulation of drugs inside nanoparticulate systems, containing targeting moieties with cell invasive properties. The bioinvasive features of the delivery system could be provided by the attachment of bacterial invasion factors, which promote efficient uptake into host cells and mediate rapid transcytosis of the pathogen through the intestinal epithelium. This review gives an overview of bacterial invasion systems. The molecular structure and function of suitable bacterial invasins, their relative values as targeting agents and possible pitfalls of their use are described. The potential of bioinvasive drug delivery systems is mainly presented on the basis of the well-characterized Yersinia invasin protein, which enters M cells to gain access to subepithelial layers of the gastrointestinal tract, but alternative approaches and future prospects for oral drug delivery are also discussed.
CitationBacterial invasion factors: Tools for crossing biological barriers and drug delivery? 2013, 84 (2):242-50 Eur J Pharm Biopharm
AffiliationDepartment of Molecular Infection Biology, Helmholtz Center for Infection Research, Braunschweig, Germany.
JournalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
The following license files are associated with this item:
- Bacterial invasin: structure, function, and implication for targeted oral gene delivery.
- Authors: Palumbo RN, Wang C
- Issue date: 2006 Jan
- Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery.
- Authors: Roger E, Lagarce F, Garcion E, Benoit JP
- Issue date: 2010 Feb
- Oral delivery of proteins by biodegradable nanoparticles.
- Authors: Bakhru SH, Furtado S, Morello AP, Mathiowitz E
- Issue date: 2013 Jun 15
- Pharmaceutical approaches to colon targeted drug delivery systems.
- Authors: Chourasia MK, Jain SK
- Issue date: 2003 Jan-Apr
- Engineered nanoparticulate drug delivery systems: the next frontier for oral administration?
- Authors: Diab R, Jaafar-Maalej C, Fessi H, Maincent P
- Issue date: 2012 Dec