PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

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Authors
Smida, Michal
Cammann, Clemens
Gurbiel, Slavyana
Kerstin, Nadja
Lingel, Holger
Lindquist, Sabine
Simeoni, Luca
Brunner-Weinzierl, Monika C
Suchanek, Miloslav
Schraven, Burkhart
Issue Date
2013

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Abstract
PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.
Citation
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. Signal
Affiliation
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany. jon.lindquist@med.ovgu.de.
Journal
Cell communication and signaling : CCS
URI
http://hdl.handle.net/10033/294281
DOI
10.1186/1478-811X-11-28
PubMed ID
23601194
Type
Article
Language
en
ISSN
1478-811X
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