PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.
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Authors
Smida, MichalCammann, Clemens
Gurbiel, Slavyana
Kerstin, Nadja
Lingel, Holger
Lindquist, Sabine
Simeoni, Luca
Brunner-Weinzierl, Monika C
Suchanek, Miloslav
Schraven, Burkhart
Lindquist, Jonathan A
Issue Date
2013
Metadata
Show full item recordAbstract
PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.Citation
PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. SignalAffiliation
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany. jon.lindquist@med.ovgu.de.PubMed ID
23601194Type
ArticleLanguage
enISSN
1478-811Xae974a485f413a2113503eed53cd6c53
10.1186/1478-811X-11-28
Scopus Count
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