PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.

Smida, Michal; Cammann, Clemens; Gurbiel, Slavyana; Kerstin, Nadja; Lingel, Holger; Lindquist, Sabine; Simeoni, Luca; Brunner-Weinzierl, Monika C; Suchanek, Miloslav; Schraven, Burkhart; Lindquist, Jonathan A

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Authors

Smida, Michal
Cammann, Clemens
Gurbiel, Slavyana
Kerstin, Nadja
Lingel, Holger
Lindquist, Sabine
Simeoni, Luca
Brunner-Weinzierl, Monika C
Suchanek, Miloslav
Schraven, Burkhart

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Issue Date

2013

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Abstract

PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.

Citation

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. Signal

Affiliation

Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, Magdeburg, 39120, Germany. jon.lindquist@med.ovgu.de.

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Article

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ISSN

1478-811X

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publications of the department of immune control (IMMK)

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