Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.
dc.contributor.author | Grenningloh, R | |
dc.contributor.author | Darj, A | |
dc.contributor.author | Bauer, H | |
dc.contributor.author | zur Lage, S | |
dc.contributor.author | Chakraborty, T | |
dc.contributor.author | Jacobs, T | |
dc.contributor.author | Weiss, S | |
dc.date.accessioned | 2008-06-23T13:21:39Z | |
dc.date.available | 2008-06-23T13:21:39Z | |
dc.date.issued | 2008-06 | |
dc.identifier.citation | Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol. | en |
dc.identifier.issn | 1365-3083 | |
dc.identifier.pmid | 18433404 | |
dc.identifier.doi | 10.1111/j.1365-3083.2008.02112.x | |
dc.identifier.uri | http://hdl.handle.net/10033/30322 | |
dc.description.abstract | Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help. | |
dc.language.iso | en | en |
dc.title | Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. | en |
dc.type | Article | en |
dc.contributor.department | Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany. | en |
dc.identifier.journal | Scandinavian journal of immunology | en |
refterms.dateFOA | 2009-06-05T00:00:00Z | |
html.description.abstract | Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help. |