Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers.

Köberle, Verena; Pleli, Thomas; Schmithals, Christian; Augusto Alonso, Eduardo; Haupenthal, Jörg; Bönig, Halvard; Peveling-Oberhag, Jan; Biondi, Ricardo M; Zeuzem, Stefan; Kronenberger, Bernd; Waidmann, Oliver; Piiper, Albrecht

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Authors

Köberle, Verena
Pleli, Thomas
Schmithals, Christian
Augusto Alonso, Eduardo
Haupenthal, Jörg
Bönig, Halvard
Peveling-Oberhag, Jan
Biondi, Ricardo M
Zeuzem, Stefan
Kronenberger, Bernd

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Issue Date

2013

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Abstract

MicroRNAs circulating in the blood, stabilized by complexation with proteins and/or additionally by encapsulation in lipid vesicles, are currently being evaluated as biomarkers. The consequences of their differential association with lipids/vesicles for their stability and use as biomarkers are largely unexplored and are subject of the present study.

Citation

Differential Stability of Cell-Free Circulating microRNAs: Implications for Their Utilization as Biomarkers. 2013, 8 (9):e75184 PLoS ONE

Affiliation

Department of Medicine I, University Hospital Frankfurt, Frankfurt, Germany.

Type

Article

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ISSN

1932-6203

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publications of the research group drug design and optimization(HIPS]DDOP)

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