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Authors
Demuth, AndreasAharonowitz, Yair
Bachmann, Till T
Blum-Oehler, Gabriele
Buchrieser, Carmen
Covacci, Antonello
Dobrindt, Ulrich
Emödy, Levente
van der Ende, Arie
Ewbank, Jonathan
Fernández, Luis Angel
Frosch, Matthias
Portillo, Francisco García-Del
Gilmore, Michael S
Glaser, Philippe
Goebel, Werner
Hasnain, Seyed E
Heesemann, Jürgen
Islam, Khalid
Korhonen, Timo
Maiden, Martin
Meyer, Thomas F
Montecucco, Cesare
Oswald, Eric
Parkhill, Julian
Pucciarelli, M Graciela
Ron, Eliora
Svanborg, Catharina
Uhlin, Bernt Eric
Wai, Sun Nyunt
Wehland, Jürgen
Hacker, Jörg
Issue Date
2008-05
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Show full item recordAbstract
The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing technologies and approaches will lead to better means of disease control. The analysis of the genome plasticity and gene pools of pathogenic bacteria including antigenic diversity and antigenic variation results in more effective vaccines and vaccine implementation programs. The study of newly identified and uncultivated microorganisms enables the identification of new threats. The scrutiny of the metabolism of the pathogen in the host allows the identification of new targets for anti-infectives and therapeutic approaches. The development of modulators of host responses and mediators of host damage will be facilitated by the research on interactions of microbes and hosts, including mechanisms of host damage, acute and chronic relationships as well as commensalisms. The study of multiple pathogenic and non-pathogenic microbes interacting in the host will improve the management of multiple infections and will allow probiotic and prebiotic interventions. Needless to iterate, the application of the results of improved prevention and treatment of infections into clinical tests will have a positive impact on the management of human and animal disease. The Pathogenomics Research Agenda draws on discussions with experts of the Network of Excellence "EuroPathoGenomics" at the management board meeting of the project held during 18-21 April 2007, in the Villa Vigoni, Menaggio, Italy. Based on a proposed European Research Agenda in the field of pathogenomics by the ERA-NET PathoGenoMics the meeting's participants updated the established list of topics as the research agenda for the future.Citation
Pathogenomics: an updated European Research Agenda. 2008, 8 (3):386-93 Infect. Genet. Evol.Affiliation
Institut für Molekulare Infektionsbiologie, Röntgenring 11, 97070 Würzburg, Germany.PubMed ID
18321793Type
ArticleLanguage
enISSN
1567-1348ae974a485f413a2113503eed53cd6c53
10.1016/j.meegid.2008.01.005
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