Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis.

Kanjarawi, Reem; Dy, Michel; Bardel, Emilie; Sparwasser, Tim; Dubois, Bertrand; Mecheri, Salah; Kaiserlian, Dominique

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Authors

Kanjarawi, Reem
Dy, Michel
Bardel, Emilie
Sparwasser, Tim
Dubois, Bertrand
Mecheri, Salah
Kaiserlian, Dominique

Issue Date

2013

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Abstract

Anaphylaxis is a life-threatening outcome of immediate-type hypersensitivity to allergen, consecutive to mast cell degranulation by allergen-specific IgE. Regulatory T cells (Treg) can control allergic sensitization and mast cell degranulation, yet their clinical benefit on anaphylactic symptoms is poorly documented. Here we investigated whether Treg action during the effector arm of the allergic response alleviates anaphylaxis.

Citation

Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. 2013, 8 (7):e69183 PLoS ONE

Affiliation

CIRI, International Center for Infectiology Research, Mucosal immunity, Vaccination & Biotherapies Team, Université de Lyon, Lyon, France.

Type

Article

Language

ISSN

1932-6203

Collections

publications of the TwinCore unit Infection immunology

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