Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis.
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Authors
Forrellad, Marina AndreaBianco, María Verónica
Blanco, Federico Calos
Nuñez, Javier
Klepp, Laura Inés
Vazquez, Cristina Lourdes
de la Santangelo, María Paz
Rocha, Rosana Valeria
Soria, Marcelo
Golby, Paul
Gutierrez, Maximiliano Gabriel
Bigi, Fabiana
Issue Date
2013-09-05
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Show full item recordAbstract
Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the agent of human tuberculosis, has developed strategies involving proteins and other compounds called virulence factors to subvert human host defences and damage and invade the human host. Among these virulence-related proteins are the Mce proteins, which are encoded in the mce1, mce2, mce3 and mce4 operons of M. tuberculosis. The expression of the mce2 operon is negatively regulated by the Mce2R transcriptional repressor. Here we evaluated the role of Mce2R during the infection of M. tuberculosis in mice and macrophages and defined the genes whose expression is in vitro regulated by this transcriptional repressor.Citation
Study of the in vivo role of Mce2R, the transcriptional regulator of mce2 operon in Mycobacterium tuberculosis. 2013, 13 (1):200 BMC Microbiol.Journal
BMC microbiologyPubMed ID
24007602Type
ArticleISSN
1471-2180ae974a485f413a2113503eed53cd6c53
10.1186/1471-2180-13-200
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