Microstructure of calcium stearate matrix pellets: a function of the drying process.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Glasser, Benjamin J
MetadataShow full item record
AbstractDrying is a common pharmaceutical process, whose potential to modify the final drug and/or dosage form properties is often underestimated. In the present study, pellets consisting of the matrix former calcium stearate (CaSt) incorporating the active pharmaceutical ingredient ibuprofen were prepared via wet extrusion and spheronization. Subsequent drying was performed by either desiccation, fluid-bed drying, or lyophilization, and the final pellets were compared with respect to their microstructure. To minimize the effect of solute ibuprofen molecules on the shrinking behavior of the CaSt, low ibuprofen loadings were used, as ibuprofen is soluble in the granulation liquid. Pellet porosity and specific surface area increased during desiccation, fluid-bed drying, and lyophilization. The inlet-air temperature during fluid-bed drying affected the specific surface area, which increased at lower inlet-air temperatures rather than the pellet porosity. The in vitro dissolution profiles were found to be a nonlinear function of the specific surface area. Overall, the microstructure, including porosity, pore size, and specific surface area, of CaSt pellets was a strong function of the drying conditions.
CitationMicrostructure of calcium stearate matrix pellets: a function of the drying process. 2013, 102 (11):3987-97 J Pharm Sci
AffiliationInstitute for Process and Particle Engineering, Graz University of Technology, Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, University of Graz, Graz, Austria.
The following license files are associated with this item:
- Ibuprofen-loaded calcium stearate pellets: drying-induced variations in dosage form properties.
- Authors: Schrank S, Hodzic A, Zimmer A, Glasser BJ, Khinast J, Roblegg E
- Issue date: 2012 Jun
- The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: pellet microstructure, drug distribution, solid state and drug dissolution.
- Authors: Schrank S, Kann B, Saurugger E, Hainschitz M, Windbergs M, Glasser BJ, Khinast J, Roblegg E
- Issue date: 2015 Jan 30
- In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation.
- Authors: Dukić-Ott A, De Beer T, Remon JP, Baeyens W, Foreman P, Vervaet C
- Issue date: 2008 Sep
- Incidence of drying on microstructure and drug release profiles from tablets of MCC-lactose-Carbopol and MCC-dicalcium phosphate-Carbopol pellets.
- Authors: Gómez-Carracedo A, Souto C, Marti Nez-Pacheco R, Concheiro A, Gómez-Amoza JL
- Issue date: 2008 Jun
- Impact of drying on solid state modifications and drug distribution in ibuprofen-loaded calcium stearate pellets.
- Authors: Schrank S, Kann B, Saurugger E, Ehmann H, Werzer O, Windbergs M, Glasser BJ, Zimmer A, Khinast J, Roblegg E
- Issue date: 2014 Feb 3