Synthesis of the spiroketal core of integramycin.
| dc.contributor.author | Prusov, Evgeny V | |
| dc.date.accessioned | 2014-01-07T10:11:33Z | |
| dc.date.available | 2014-01-07T10:11:33Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | Synthesis of the spiroketal core of integramycin. 2013, 9:2446-50 Beilstein J Org Chem | en |
| dc.identifier.issn | 1860-5397 | |
| dc.identifier.pmid | 24367411 | |
| dc.identifier.doi | 10.3762/bjoc.9.282 | |
| dc.identifier.uri | http://hdl.handle.net/10033/310994 | |
| dc.description.abstract | A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Beilstein journal of organic chemistry | en |
| dc.title | Synthesis of the spiroketal core of integramycin. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Medicinal Chemistry, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany | en |
| dc.identifier.journal | Beilstein journal of organic chemistry | en |
| refterms.dateFOA | 2018-06-13T00:25:02Z | |
| html.description.abstract | A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated. |
