Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.

Nandakumar, Ramya; Finsterbusch, Katja; Lipps, Christoph; Neumann, Berit; Grashoff, Martina; Nair, Sharmila; Hochnadel, Inga; Lienenklaus, Stefan; Wappler, Ilka; Steinmann, Eike; Hauser, Hansjörg; Pietschmann, Thomas; Kröger, Andrea

dc.contributor.author	Nandakumar, Ramya
dc.contributor.author	Finsterbusch, Katja
dc.contributor.author	Lipps, Christoph
dc.contributor.author	Neumann, Berit
dc.contributor.author	Grashoff, Martina
dc.contributor.author	Nair, Sharmila
dc.contributor.author	Hochnadel, Inga
dc.contributor.author	Lienenklaus, Stefan
dc.contributor.author	Wappler, Ilka
dc.contributor.author	Steinmann, Eike
dc.contributor.author	Hauser, Hansjörg
dc.contributor.author	Pietschmann, Thomas
dc.contributor.author	Kröger, Andrea
dc.date.accessioned	2014-01-16T15:27:18Z	en
dc.date.available	2014-01-16T15:27:18Z	en
dc.date.issued	2013-12	en
dc.identifier.citation	Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms. 2013, 145 (6):1414-23.e1 Gastroenterology	en
dc.identifier.issn	1528-0012	en
dc.identifier.pmid	23973921	en
dc.identifier.doi	10.1053/j.gastro.2013.08.037	en
dc.identifier.uri	http://hdl.handle.net/10033/311411	en
dc.description.abstract	Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50% of patients control HCV infection after treatment, but the broad range of patients' outcomes and responses to treatment, among all genotypes, indicates a role for host factors. Although the IFN system is important in limiting HCV replication, the virus has evolved mechanisms to circumvent the IFN response. However, direct, IFN-independent antiviral processes also might help control HCV replication. We examined the role of IFN-independent responses against HCV replication.
dc.language.iso	en	en
dc.rights	Archived with thanks to Gastroenterology	en
dc.title	Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.	en
dc.type	Article	en
dc.contributor.department	Helmholtz Centre for infection research, D38124 Braunschweig, Germany	en
dc.identifier.journal	Gastroenterology	en
refterms.dateFOA	2018-06-13T09:08:20Z
html.description.abstract	Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50% of patients control HCV infection after treatment, but the broad range of patients' outcomes and responses to treatment, among all genotypes, indicates a role for host factors. Although the IFN system is important in limiting HCV replication, the virus has evolved mechanisms to circumvent the IFN response. However, direct, IFN-independent antiviral processes also might help control HCV replication. We examined the role of IFN-independent responses against HCV replication.