Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.

Steinbach, Anke; Maurer, Christine K; Weidel, Elisabeth; Henn, Claudia; Brengel, Christian; Hartmann, Rolf W; Negri, Matthias

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Authors

Steinbach, Anke
Maurer, Christine K
Weidel, Elisabeth
Henn, Claudia
Brengel, Christian
Hartmann, Rolf W
Negri, Matthias

Issue Date

2013

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Abstract

PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ.

Citation

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies. 2013, 6 (1):10 BMC Biophys

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Article

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ISSN

2046-1682

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publications of the research group drug design and optimization(HIPS]DDOP)

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