Multifunctional silica nanoparticles for optical and magnetic resonance imaging.
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Authors
Joshi, RajendraFeldmann, Verena
Koestner, Wolfgang
Detje, Claudia
Gottschalk, Sven
Mayer, Hermann A
Sauer, Martin G
Engelmann, Jörn
Issue Date
2013-01
Metadata
Show full item recordAbstract
The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.Citation
Multifunctional silica nanoparticles for optical and magnetic resonance imaging. 2013, 394 (1):125-35 Biol. Chem.Affiliation
Institute for Experimental Infection Research, TWINCORE , Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Straβe 7, D-30625 Hannover, GermanyJournal
Biological chemistryPubMed ID
23096570Type
ArticleLanguage
enISSN
1437-4315ae974a485f413a2113503eed53cd6c53
10.1515/hsz-2012-0251
Scopus Count
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