Human and animal isolates of Yersinia enterocolitica show significant serotype-specific colonization and host-specific immune defense properties.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractYersinia enterocolitica is a human pathogen that is ubiquitous in livestock, especially pigs. The bacteria are able to colonize the intestinal tract of a variety of mammalian hosts, but the severity of induced gut-associated diseases (yersiniosis) differs significantly between hosts. To gain more information about the individual virulence determinants that contribute to colonization and induction of immune responses in different hosts, we analyzed and compared the interactions of different human- and animal-derived isolates of serotypes O:3, O:5,27, O:8, and O:9 with murine, porcine, and human intestinal cells and macrophages. The examined strains exhibited significant serotype-specific cell binding and entry characteristics, but adhesion and uptake into different host cells were not host specific and were independent of the source of the isolate. In contrast, survival and replication within macrophages and the induced proinflammatory response differed between murine, porcine, and human macrophages, suggesting a host-specific immune response. In fact, similar levels of the proinflammatory cytokine macrophage inflammatory protein 2 (MIP-2) were secreted by murine bone marrow-derived macrophages with all tested isolates, but the equivalent interleukin-8 (IL-8) response of porcine bone marrow-derived macrophages was strongly serotype specific and considerably lower in O:3 than in O:8 strains. In addition, all tested Y. enterocolitica strains caused a considerably higher level of secretion of the anti-inflammatory cytokine IL-10 by porcine than by murine macrophages. This could contribute to limiting the severity of the infection (in particular of serotype O:3 strains) in pigs, which are the primary reservoir of Y. enterocolitica strains pathogenic to humans.
CitationHuman and animal isolates of Yersinia enterocolitica show significant serotype-specific colonization and host-specific immune defense properties. 2013, 81 (11):4013-25 Infect. Immun.
AffiliationDept. of molecular infection biology, Helmholtz Centre for infection biology, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
JournalInfection and immunity
The following license files are associated with this item:
- Unique virulence properties of Yersinia enterocolitica O:3--an emerging zoonotic pathogen using pigs as preferred reservoir host.
- Authors: Valentin-Weigand P, Heesemann J, Dersch P
- Issue date: 2014 Oct
- Yersinia enterocolitica isolates of differing biotypes from humans and animals are adherent, invasive and persist in macrophages, but differ in cytokine secretion profiles in vitro.
- Authors: McNally A, Dalton T, Ragione RM, Stapleton K, Manning G, Newell DG
- Issue date: 2006 Dec
- Comparison of Growth and the Cytokines Induced by Pathogenic Yersinia enterocolitica Bio-Serotypes 3/O: 3 and 2/O: 9.
- Authors: Yang H, Gu W, Qiu H, Sun G, Liang J, Li K, Xiao Y, Duan R, Jing H, Wang X
- Issue date: 2017
- An aflagellate mutant Yersinia enterocolitica biotype 1A strain displays altered invasion of epithelial cells, persistence in macrophages, and cytokine secretion profiles in vitro.
- Authors: McNally A, La Ragione RM, Best A, Manning G, Newell DG
- Issue date: 2007 May
- Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis.
- Authors: Uliczka F, Pisano F, Schaake J, Stolz T, Rohde M, Fruth A, Strauch E, Skurnik M, Batzilla J, Rakin A, Heesemann J, Dersch P
- Issue date: 2011 Jul