Computational Study to Determine When to Initiate and Alternate Therapy in HIV Infection.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractHIV is a widespread viral infection without cure. Drug treatment has transformed HIV disease into a treatable long-term infection. However, the appearance of mutations within the viral genome reduces the susceptibility of HIV to drugs. Therefore, a key goal is to extend the time until patients exhibit resistance to all existing drugs. Current HIV treatment guidelines seem poorly supported as practitioners have not achieved a consensus on the optimal time to initiate and to switch antiretroviral treatments. We contribute to this discussion with predictions derived from a mathematical model of HIV dynamics. Our results indicate that early therapy initiation (within 2 years postinfection) is critical to delay AIDS progression. For patients who have not received any therapy during the first 3 years postinfection, switch in response to virological failure may outperform proactive switching strategies. In case that proactive switching is opted, the switching time between therapies should not be larger than 100 days. Further clinical trials are needed to either confirm or falsify these predictions.
CitationComputational Study to Determine When to Initiate and Alternate Therapy in HIV Infection. 2014, 2014:472869 Biomed Res Int
JournalBioMed research international
The following license files are associated with this item:
- Long-term immune and virological response in HIV-infected patients receiving antiretroviral therapy.
- Authors: Silveira MP, Silveira CP, Guttier MC, Page K, Moreira LB
- Issue date: 2016 Dec
- A Markov model for the effects of virological failure on HIV/AIDS progression in tuberculosis co-infected patients receiving antiretroviral therapy in a rural clinic in northern South Africa.
- Authors: Shoko C, Chikobvu D, Bessong PO
- Issue date: 2020 Mar 30
- Guidelines for using antiretroviral agents among HIV-infected adults and adolescents.
- Authors: Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK, Panel on Clinical Practices for Treatment of HIV.
- Issue date: 2002 Sep 3
- Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Recommendations of the Panel on Clinical Practices for Treatment of HIV.
- Authors: Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK, Panel on Clinical Practices for the Treatment of HIV.
- Issue date: 2002 May 17
- API consensus guidelines for use of antiretroviral therapy in adults (API-ART guidelines). Endorsed by the AIDS Society of India.
- Authors: Gupta SB, Pujari SN, Joshi SR, Patel AK, AIDS Society of India Guidelines Development Committee.
- Issue date: 2006 Jan