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dc.contributor.authorSudhakar, Padhmanand
dc.contributor.authorReck, Michael
dc.contributor.authorWang, Wei
dc.contributor.authorHe, Feng Q
dc.contributor.authorDobler, Irene W
dc.contributor.authorZeng, An-Ping
dc.date.accessioned2014-07-11T14:15:35Zen
dc.date.available2014-07-11T14:15:35Zen
dc.date.issued2014en
dc.identifier.citationConstruction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. 2014, 15:362 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid24884510en
dc.identifier.doi10.1186/1471-2164-15-362en
dc.identifier.urihttp://hdl.handle.net/10033/322836en
dc.description.abstractCarolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out.
dc.language.isoenen
dc.rightsArchived with thanks to BMC genomicsen
dc.titleConstruction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.en
dc.typeArticleen
dc.identifier.journalBMC genomicsen
refterms.dateFOA2018-06-13T05:31:19Z
html.description.abstractCarolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out.


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