Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.
dc.contributor.author | Sudhakar, Padhmanand | |
dc.contributor.author | Reck, Michael | |
dc.contributor.author | Wang, Wei | |
dc.contributor.author | He, Feng Q | |
dc.contributor.author | Dobler, Irene W | |
dc.contributor.author | Zeng, An-Ping | |
dc.date.accessioned | 2014-07-11T14:15:35Z | en |
dc.date.available | 2014-07-11T14:15:35Z | en |
dc.date.issued | 2014 | en |
dc.identifier.citation | Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. 2014, 15:362 BMC Genomics | en |
dc.identifier.issn | 1471-2164 | en |
dc.identifier.pmid | 24884510 | en |
dc.identifier.doi | 10.1186/1471-2164-15-362 | en |
dc.identifier.uri | http://hdl.handle.net/10033/322836 | en |
dc.description.abstract | Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to BMC genomics | en |
dc.title | Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. | en |
dc.type | Article | en |
dc.identifier.journal | BMC genomics | en |
refterms.dateFOA | 2018-06-13T05:31:19Z | |
html.description.abstract | Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out. |