Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
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Authors
Weiss, Jonathan MBilate, Angelina M
Gobert, Michael
Ding, Yi
Curotto de Lafaille, Maria A
Parkhurst, Christopher N
Xiong, Huizhong
Dolpady, Jayashree
Frey, Alan B
Ruocco, Maria Grazia
Yang, Yi
Floess, Stefan
Huehn, Jochen
Oh, Soyoung
Li, Ming O
Niec, Rachel E
Rudensky, Alexander Y
Dustin, Michael L
Littman, Dan R
Lafaille, Juan J
Issue Date
2012-09-24
Metadata
Show full item recordAbstract
Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease.Citation
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. 2012, 209 (10):1723-42, S1 J. Exp. Med.PubMed ID
22966001Type
ArticleLanguage
enISSN
1540-9538ae974a485f413a2113503eed53cd6c53
10.1084/jem.20120914
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