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dc.contributor.authorFang, Kechi
dc.contributor.authorZhao, Hansheng
dc.contributor.authorSun, Changyue
dc.contributor.authorLam, Carolyn M C
dc.contributor.authorChang, Suhua
dc.contributor.authorZhang, Kunlin
dc.contributor.authorPanda, Gurudutta
dc.contributor.authorGodinho, Miguel
dc.contributor.authorMartins dos Santos, Vítor A P
dc.contributor.authorWang, Jing
dc.date.accessioned2014-08-07T13:05:02Z
dc.date.available2014-08-07T13:05:02Z
dc.date.issued2011
dc.identifier.citationExploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. 2011, 5:83 BMC Syst Biolen
dc.identifier.issn1752-0509
dc.identifier.pmid21609491
dc.identifier.doi10.1186/1752-0509-5-83
dc.identifier.urihttp://hdl.handle.net/10033/324347
dc.description.abstractBurkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.
dc.language.isoenen
dc.rightsArchived with thanks to BMC systems biologyen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBiomassen
dc.subject.meshBurkholderia Infectionsen
dc.subject.meshBurkholderia cenocepaciaen
dc.subject.meshCatalysisen
dc.subject.meshComputational Biologyen
dc.subject.meshDrug Resistance, Bacterialen
dc.subject.meshFatty Acidsen
dc.subject.meshGenomeen
dc.subject.meshGenome, Bacterialen
dc.subject.meshHumansen
dc.subject.meshLipopolysaccharidesen
dc.subject.meshModels, Biologicalen
dc.subject.meshModels, Statisticalen
dc.subject.meshPhenotypeen
dc.subject.meshSystems Biologyen
dc.titleExploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.en
dc.typeArticleen
dc.identifier.journalBMC systems biologyen
refterms.dateFOA2018-06-13T14:09:05Z
html.description.abstractBurkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.


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