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dc.contributor.authorCrull, Katja
dc.contributor.authorBumann, Dirk
dc.contributor.authorWeiss, Siegfried
dc.date.accessioned2014-08-13T14:01:52Z
dc.date.available2014-08-13T14:01:52Z
dc.date.issued2011-06
dc.identifier.citationInfluence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium. 2011, 62 (1):75-83 FEMS Immunol. Med. Microbiol.en
dc.identifier.issn1574-695X
dc.identifier.pmid21314734
dc.identifier.doi10.1111/j.1574-695X.2011.00790.x
dc.identifier.urihttp://hdl.handle.net/10033/324764
dc.description.abstractAdministration of facultative anaerobic bacteria such as Salmonella enterica serovar Typhimurium as anticancer treatment holds a great therapeutic potential. Here, we tested different routes of application of S. typhimurium with regard to tumor colonization and therapeutic efficacy. No differences between intravenous and intraperitoneal infection were observed, often leading to a complete tumor clearance. In contrast, after oral application, tumor colonization was inefficient and delayed. No therapeutic effect was observed under such conditions. We also showed that tumor invasion and colonization were independent of functional Salmonella pathogenicity island (SPI) 1 and SPI 2. Furthermore, tumor invasion and colonization did not require bacterial motility or chemotactic responsiveness. The distribution of the bacteria within the tumor was independent of such functions.
dc.language.isoenen
dc.rightsArchived with thanks to FEMS immunology and medical microbiologyen
dc.subject.meshAdministration, Oralen
dc.subject.meshAnimalsen
dc.subject.meshCarcinomaen
dc.subject.meshColonic Neoplasmsen
dc.subject.meshDrug Administration Routesen
dc.subject.meshFemaleen
dc.subject.meshInjections, Intraperitonealen
dc.subject.meshInjections, Intravenousen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshNeoplasms, Experimentalen
dc.subject.meshSalmonella typhimuriumen
dc.subject.meshTreatment Outcomeen
dc.subject.meshVirulenceen
dc.subject.meshVirulence Factorsen
dc.titleInfluence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium.en
dc.typeArticleen
dc.contributor.departmentDept. Molecular Immunology, Helmholtz Centre for infection research, Inhoffenstr. 7, D38124 Braunschweig, Germany.en
dc.identifier.journalFEMS immunology and medical microbiologyen
refterms.dateFOA2018-06-12T22:36:19Z
html.description.abstractAdministration of facultative anaerobic bacteria such as Salmonella enterica serovar Typhimurium as anticancer treatment holds a great therapeutic potential. Here, we tested different routes of application of S. typhimurium with regard to tumor colonization and therapeutic efficacy. No differences between intravenous and intraperitoneal infection were observed, often leading to a complete tumor clearance. In contrast, after oral application, tumor colonization was inefficient and delayed. No therapeutic effect was observed under such conditions. We also showed that tumor invasion and colonization were independent of functional Salmonella pathogenicity island (SPI) 1 and SPI 2. Furthermore, tumor invasion and colonization did not require bacterial motility or chemotactic responsiveness. The distribution of the bacteria within the tumor was independent of such functions.


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