Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers.
dc.contributor.author | Arnold, Philipp | |
dc.contributor.author | Himmels, Patricia | |
dc.contributor.author | Weiß, Svenja | |
dc.contributor.author | Decker, Tim-Michael | |
dc.contributor.author | Markl, Jürgen | |
dc.contributor.author | Gatterdam, Volker | |
dc.contributor.author | Tampé, Robert | |
dc.contributor.author | Bartholomäus, Patrick | |
dc.contributor.author | Dietrich, Ursula | |
dc.contributor.author | Dürr, Ralf | |
dc.date.accessioned | 2014-09-12T10:54:52Z | |
dc.date.available | 2014-09-12T10:54:52Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. 2014, 11:42 Retrovirology | en |
dc.identifier.issn | 1742-4690 | |
dc.identifier.pmid | 24884925 | |
dc.identifier.doi | 10.1186/1742-4690-11-42 | |
dc.identifier.uri | http://hdl.handle.net/10033/326070 | |
dc.description.abstract | HIV-1 is decorated with trimeric glycoprotein spikes that enable infection by engaging CD4 and a chemokine coreceptor, either CCR5 or CXCR4. The variable loop 3 (V3) of the HIV-1 envelope protein (Env) is the main determinant for coreceptor usage. The predominant CCR5 using (R5) HIV-1 Env has been intensively studied in function and structure, whereas the trimeric architecture of the less frequent, but more cytopathic CXCR4 using (X4) HIV-1 Env is largely unknown, as are the consequences of sequence changes in and near V3 on antigenicity and trimeric Env structure. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Retrovirology | en |
dc.title | Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. | en |
dc.type | Article | en |
dc.identifier.journal | Retrovirology | en |
refterms.dateFOA | 2018-06-13T04:20:50Z | |
html.description.abstract | HIV-1 is decorated with trimeric glycoprotein spikes that enable infection by engaging CD4 and a chemokine coreceptor, either CCR5 or CXCR4. The variable loop 3 (V3) of the HIV-1 envelope protein (Env) is the main determinant for coreceptor usage. The predominant CCR5 using (R5) HIV-1 Env has been intensively studied in function and structure, whereas the trimeric architecture of the less frequent, but more cytopathic CXCR4 using (X4) HIV-1 Env is largely unknown, as are the consequences of sequence changes in and near V3 on antigenicity and trimeric Env structure. |