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dc.contributor.authorArnold, Philipp
dc.contributor.authorHimmels, Patricia
dc.contributor.authorWeiß, Svenja
dc.contributor.authorDecker, Tim-Michael
dc.contributor.authorMarkl, Jürgen
dc.contributor.authorGatterdam, Volker
dc.contributor.authorTampé, Robert
dc.contributor.authorBartholomäus, Patrick
dc.contributor.authorDietrich, Ursula
dc.contributor.authorDürr, Ralf
dc.date.accessioned2014-09-12T10:54:52Z
dc.date.available2014-09-12T10:54:52Z
dc.date.issued2014
dc.identifier.citationAntigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers. 2014, 11:42 Retrovirologyen
dc.identifier.issn1742-4690
dc.identifier.pmid24884925
dc.identifier.doi10.1186/1742-4690-11-42
dc.identifier.urihttp://hdl.handle.net/10033/326070
dc.description.abstractHIV-1 is decorated with trimeric glycoprotein spikes that enable infection by engaging CD4 and a chemokine coreceptor, either CCR5 or CXCR4. The variable loop 3 (V3) of the HIV-1 envelope protein (Env) is the main determinant for coreceptor usage. The predominant CCR5 using (R5) HIV-1 Env has been intensively studied in function and structure, whereas the trimeric architecture of the less frequent, but more cytopathic CXCR4 using (X4) HIV-1 Env is largely unknown, as are the consequences of sequence changes in and near V3 on antigenicity and trimeric Env structure.
dc.language.isoenen
dc.rightsArchived with thanks to Retrovirologyen
dc.titleAntigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers.en
dc.typeArticleen
dc.identifier.journalRetrovirologyen
refterms.dateFOA2018-06-13T04:20:50Z
html.description.abstractHIV-1 is decorated with trimeric glycoprotein spikes that enable infection by engaging CD4 and a chemokine coreceptor, either CCR5 or CXCR4. The variable loop 3 (V3) of the HIV-1 envelope protein (Env) is the main determinant for coreceptor usage. The predominant CCR5 using (R5) HIV-1 Env has been intensively studied in function and structure, whereas the trimeric architecture of the less frequent, but more cytopathic CXCR4 using (X4) HIV-1 Env is largely unknown, as are the consequences of sequence changes in and near V3 on antigenicity and trimeric Env structure.


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